AMAZON A – P

THE AMAZON SUPPORT RANGE©

Now you can share the knowledge of the Shaman’s

A synergistic formula of 10 rainforest botanicals traditionally used in South America for parasites.

For more information on the individual ingredients in Amazon A-P, follow the links provided below to the plant database files in the Tropical Plant Database.

Each rainforest botanical in this professional formula has been sustainably harvested in the Amazon Rainforest and documented with antiparasitic properties. To learn more about our rainforest ingredients and wild harvesting methods please visit the plant database.

Price: £21.95 – 120 Capsules

This product contains no binders, fillers, or exipients and is 100% finely milled natural plants. This product is backed by Raintree’s unconditional guarantee

Ingredients:

A proprietary blend of amargo, simarouba, boldo, fedegoso, carqueja, quinine, erva tostão, epazote, anamu, and graviola.

This formula is 100% pure natural ground plants. No binders, fillers or other additives are used. These plants have grown naturally in the richness of the Amazon without any pesticides or fertilizers and they are non-irradiated and non-fumigated.

Suggested Use: Take 2-3 capsules twice daily with meals (depending on body weight).

Contraindications: Not to be used during pregnancy or while breast-feeding.

Drug Interactions: None reported.

Other Practitioner Observations:

Several plants in this formula have been documented with hypotensive properties in animal studies.

Individuals with low blood pressure should be monitored more closely for this possible effect.

This formula is more effective if taken consecutively for a minimum of 40 days.

Do not exceed 9 capsules daily. Exceeding recommended amount may cause stomach cramps.

A powerful formula of rainforest botanicals which are used by the shamans and herbal healers in South America.

For example one form of parasite infestation can cause Elephantitis, or Elephantiasis.

True elephantiasis is the result of a parasitic infection caused by three specific kinds of round worms. The long, threadlike worms block the body’s lymphatic system–a network of channels, lymph nodes, and organs that helps maintain proper fluid levels in the body by draining lymph from tissues into the bloodstream.

This blockage causes fluids to collect in the tissues, which can lead to great swelling, called “lymphedema.” Limbs can swell so enormously that they resemble an elephant’s foreleg in size, texture, and color. This is the severely disfiguring and disabling condition of elephantiasis.

There are a few different causes of elephantiasis, but the agents responsible for most of the elephantiasis in the world are filarial worms: white, slender round worms found in most tropical and subtropical places.

They are transmitted by particular kinds (species) of mosquitoes, that is, bloodsucking insects. Infection with these worms is called “lymphatic filariasis” and over a long period of time can cause elephantiasis. Click here for more details of Elephantiasis

Anti-Parasite Support combines these wonderful rainforest remedies for parasites for a truly dynamic and effective formula.

For more in-depth information on these unique and highly effective rainforest plants, click on the ingredient names below to go to the database entry file for each rainforest plant.

A proprietary blend of amargo,anamu, simarouba, boldo, carqueja,,epazote, erva tostão, edegoso, and graviola.f quinine

Herbal Ingredients

Amargo

Anamu

Boldo

Carqueja

Epazote

Ervatostao

Fedegosa

Graviola

Quinine

Simaruba

Here is a list of the herbal extracts used in this product. However in our quest for improvement and excellence, our products are being continually reviewed and modified as more data on the various plants becomes available.

As a result, the ingredients may be subject to change. Any changes will be reflected in the above list as soon as we have time to make the necessary updates. Thank You.

Third-Party Published Research*

This formulated product has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Amargo (Quassia amara)

Laboratory studies on amargo and its chemicals reports the bark possesses antiparasitic, anti-amebic, and antimalarial actions.*

Bertani, S., et al. “Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation.” J. Ethnopharmacol. 2006 Nov 6;

Bertani, S., et al. “Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae).” J. Ethnopharmacol. 2006 Nov 3;108(1):155-7.

Vigneron, M., et al. “Antimalarial remedies in French Guiana: a knowledge attitudes and practices study.” J. Ethnopharmacol. 2005 Apr; 98(3): 351-60.

Bertani, S., et al. “Evaluation of French Guiana traditional antimalarial remedies.” J. Ethnopharmacol. 2005 Apr; 98(1-2): 45-54.

Ajaiyeoba, E. O., et al. “In vivo antimalarial activities of Quassia amara and Quassia undulata plant extracts in mice.” J. Ethnopharmacol. 1999; 67(3): 321–25.

O’Neill, M. J., et al. “Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.” Antimicrob. Agents Chemother. 1986; 30(1): 101–4.

Trager, W., et al. “Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro.” Am. J. Trop. Med. Hyg. 1981; 30(3): 531–37.

Garcia Gonzalez, M., et al. “Pharmacologic activity of the aqueous wood extract from Quassia amara (Simarubaceae) on albino rats and mice.” Rev. Biol. Trop. 1997; 44–45: 47–50.

Ninci, M. E. “Prophylaxis and treatment of pediculosis [lice] with Quassia amarga.” Rev. Fac. Cien. Med. Univ. Nac. Cordoba 1991; 49(2): 27–31.

Wright, C. W., et al. “Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.” Antimicrob. Agents Chemother. 1988; 32(11): 1725-9.

Simarouba (Simarouba amara)

The main active group of chemicals in simarouba are called quassinoids which are well known to scientists. The antiprotozoal and antimalarial properties of these chemicals have been documented for many years.* Several of the quassinoids found in simarouba, such as ailanthinone, glaucarubinone, and holacanthone, are considered the plant’s main constituents and are the ones documented to be antiprotozal, anti-amebic, and antimalarial.*

Francois, G., et al. ”Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships.” Int. J. Parasitol. 1998; 28(4): 635-40.

Franssen, F. F., et al. “In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.” Antimicrob. Agents Chemother. 1997; 41(7): 1500–3.

Wright, C. W., et al. “Quassinoids exhibit greater selectivity against Plasmodium falciparum than against Entamoeba histoyltica, Giardia intestinalis or Toxoplasma gondii in vitro.” J. Eukaryot. Microbiol. 1993; 40(3): 244–46.

Kirby, G. C., et al. “In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.” Biochem. Pharmacol. 1989; 38(24): 4367–74.

O’Neill, M. J., et al. “Plants as sources of antimalarial drugs, Part 6. Activities of Simarouba amara fruits.” J. Ethnopharmacol. 1988; 22(2): 183–90.

O’Neill, M. J., et al. “The activity of Simarouba amara against chloroquine-resistant Plasmodium falciparum in vitro.” J. Pharm. Pharmacol. 1987; Suppl. 39: 80.

Monjour, I., et al. “Therapeutic trials of experimental murine malaria with the quassinoid, glaucarubinone.” C. R. Acad. Sci. Ill. 1987; 304(6): 129–32.

Trager, W., et al. “Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro.” Am. J. Trp. Med. Hyg. 1981; 30(3): 531–37.

Duriez, R., et al. “Glaucarubin in the treatment of amebiasis.” Presse Med. 1962; 70: 1291.

Spencer, C. F., et al. “Survey of plants for antimalarial activity.” Lloydia 1947; 10: 145–74.

Cuckler, A. C., et al. “Efficacy and toxicity of simaroubidin in experimental amoebiasis.” Fed. Proc. 1944; 8: 284.

Shepheard, S., et al. “Persistent carriers of Entameba histolytica.” Lancet 1918: 501.

Boldo (Peumus boldus)

Boldo (Peumus boldus) Boldo leaves contains a phytochemical called asaridole (which is also found in epazote). This plant chemical has been documented to possess antiparasitic, antimalarial, and vermifuge (worm-expelling) properties.*

Okuyama, E., et al. “ Ascaridole as a pharmacologically active principle of “Paico,” a medicinal Peruvian plant.” Chem. Pharm. Bull. 1993; 41(7): 1309-11.

Pollack, Y., et al. “The effect of ascaridole on the in vitro development of Plasmodium falciparum.” Parasitol. Res. 1990; 76(7): 570-2.

Morello, A., et al. “Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi.” Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 1994; 107(3): 367-71.

Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955-60.

Peters, W., et al. “The chemotherapy of rodent malaria. XLVIII. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 1: Studies leading to the development of novel cis-fused cyclopenteno derivatives.” Ann. Trop. Med. Parasitol. 1993 Feb; 87(1): 1-7.

Fedegoso (Cassia occidentalis)

Fedegoso has also been used for many types of parasitic infections for many years in the tropical countries where it grows.* In vitro research on fedegoso over the years has reported antiparasitic, insecticidal, and antimalarial properties.*

Schmeda-Hirschmann, G., et al. “A screening method for natural products on triatomine bugs.” Phytother. Res. 1989; 6(2): 68–7

Tona, L., et al. “In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo.” J. Ethnopharmacol. 2004 Jul; 93(1): 27-32.

Tona, L., et al. “In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.” Ann. Trop. Med. Parasitol. 2001; 95(1): 47–57.

Tona, L., et al. “Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo.” J. Ethnopharmacol. 1999 Dec 15; 68(1-3): 193-203.

Gasquet, M., et al. “Evaluation in vitro and in vivo of a traditional antimalarial, ‘Malarial 5.'” Fitoterapia. 1993; 64(5): 423.

Carqueja (Baccharis genistelloides, trimera)

Several novel plant chemicals called clerodane diterpenoids have been identified in carqueja and, in 1994, scientists showed that these chemicals had maximum effects against worms.* This could possibly explain carqueja’s long history of use as an agent to expel intestinal worms.*

Sosa, M. E., et al. “Insect antifeedant activity of clerodane diterpenoids.” J. Nat. Prod. 1994; 57(9): 1262–

Herz, W., et al. “New ent-clerodane-type diterpenoids from Baccharis trimera.” J. Org. Chem. 1977 Nov 25; (24): 42.

Gonzales, E., et al. “Gastric cytoprotection of Bolivian medicinal plants.” J. Ethnopharmacol. 2000; 70(3): 329–33.

Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep 20; 496(1-2): 33–8.

Quinine (Cinchona succirubra)

In European herbal medicine quinine bark is considered antiprotozoal, antispasmodic, antimalarial, a bitter tonic, and a fever-reducer.* Quinine bark has long been documented with antiparasitic and antimalarial actions in laboratory studies.*

Bertani, S., et al. “Evaluation of French Guiana traditional antimalarial remedies.” J. Ethnopharmacol. 2005 Apr; 98(1-2): 45-54.

Pukrittayakamee, S., et al. “Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria.” Antimicrob. Agents Chemother. 2003; 47(11): 3458-63.

Warhurst, D. C., et al. “The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. Malar. J. 2003 Sep 01; 2(1):26.

Pussard, E., et al. “Quinine distribution in mice with Plasmodium berghei malaria.” Eur. J. Drug Metab. Pharmacokinet. 2003 Jan-Mar; 28(1): 11-20.

Nakajima, Y. “Antiprotozoal drugs.” Nippon Rinsho. 2003 Feb; 61 Suppl 2: 774-9.

Vieira, J. L., et al. “Drug monitoring of quinine in men with nonsevere falciparum malaria: study in the Amazon region of Brazil.” Ther. Drug Monit. 2001 Dec; 23(6): 612-5.

Tagboto, S., et al. “Antiparasitic properties of medicinal plants and other naturally occurring products.” Adv. Parasitol. 2001; 50: 199-295.

Aviado, D. M., et al. “Antimalarial and antiarrhythmic activity of plant extracts.” Medicina Experimentalis—International Journal of Experimental Medicine 1969; 19(20), 79–94.

Erva Tostão (Boerhaavia diffusa)

Laboratory studies document that erva tostão has anti-amebic actions in animal studies and in vitro studies.*

Hilou, A., et al. “In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice.” J. Ethnopharmacol. 2006 Jan; 103(2): 236-40.

Sohni, Y., et al. “The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo.” J. Ethnopharmacol. 1995; 45 1: 43–52.

Sohni, Y. R., et al. “Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies.” J. Ethnopharmacol. 1996 Nov; 54(2-3): 119–24.

Vijayalakshimi, K., et al. “Nematicidal properties of some indigenous plant materials against second stage juveniles of Meloidogyne incognita (koffoid and white) chitwood.” Indian J. Entomol. 1979; 4(4): 326–331.

Borrelli F, et al. “Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility.” Planta Med. 2005; 71(10): 928-32.

Epazote (Chenopodium ambrosioides)

In a 1996 study, epazote was given to 72 children and adults with intestinal parasitic infections.* On average, the study reported an antiparasitic efficacy in 56% of cases. With respect to the tested parasites, epazote was reported to be 100% effective against the common intestinal parasites, Ancilostoma and Trichuris, and, 50% effective against Ascaris (round worm).* In a more recent study in 2001, thirty children with intestinal roundworms were treated with epazote. Disappearance of the ascaris eggs occurred in 86.7%, while the parasitic burden decreased in 59.5%.* In addition, this study also reported that epazote was 100% effective in eliminating the common human tapeworm (Hymenolepsis nana).*

Monzote, L., et al. “Activity of the essential oil from Chenopodium ambrosioides grown in Cuba against Leishmania amazonensis.” Chemotherapy. 2006; 52(3): 130-6.

Chiasson, H., et al. “Acaricidal properties of a Chenopodium-based botanical.” J. Econ. Entomol. 2004 Aug; 97(4): 1373-7.

Lopez de Guimaraes, D., et al. “Ascariasis: comparison of the therapeutic efficacy between paico and albendazole in children from Huaraz.” Rev. Gastroenterol 2001; 21(3): 212-9.

Giove Nakazawa, R. A. “Traditional medicine in the treatment of enteroparasitosis.” Rev. Gastroenterol.1996; 16(3): 197-202.

Kliks, M. M., et al. “Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: Ethnopharmacological evaluation and clinical field trials.” Soc. Sci. Med. 1985; 21(8): 879-86.

Quinlan, M. B., et al. “Ethnophysiology and herbal treatments of intestinal worms in Dominica, West Indies.” J. Ethnopharmacol. 2002; 80(1): 75-83.

Kiuchi, F., et al. “Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides.” J. Nat. Prod. 2002; 65(4): 509-12.

Anamu (Petiveria alliacea)

Anamu’s antimicrobial activity was demonstrated by researchers from Guatemala and Austria who, in separate studies in 1998, confirmed its activity in vitro and in vivo studies against several strains of protozoa, bacteria, and fungi.*

Caceres, A., et al. “Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plants.” J. Ethnopharmacol. 1998 Oct; 62(3): 195–202.

Berger I., et al. “Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi.” J. Ethnopharmacol. 1998 Sep; 62(2): 107-15.

Kim, S., et al. “Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 188-92.

Graviola (Annona muricata)

Graviola contains chemicals called Annonaceous acetogenins which have been documented and patented as antiparasitic and insecticidal agents.*

Bories, C., et al. “Antiparasitic activity of Annona muricata and Annona cherimolia seeds.” Planta Med. 1991; 57(5): 434-36.

Mesquita, M. L., et al. “Antileishmanial and trypanocidal activity of Brazilian Cerrado plants.” Mem. Inst. Oswaldo Cruz. 2005 Nov; 100(7): 783-7.

Githiori, J. B., et al. “Evaluation of anthelmintic properties of some plants used as livestock dewormers against Haemonchus contortus infections in sheep.” Parasitology. 2004 Aug; 129(Pt 2): 245-53.

Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000 Apr; 71(2): 183-6.

Heinrich, M., et al. “Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico).” J. Ethnopharmacol. 1992; (36)1: 81-5.

Antoun, M. D., et al. “Screening of the flora of Puerto Rico for potential antimalarial bioactives.” Int. J. Pharmacog. 1993; 31(4): 255-58.

Tattersfield, F., et al. “The insecticidal properties of certain species of Annona and an Indian strain of Mundulea sericea (Supli).” Ann. Appl. Biol. 1940; 27: 262-73.

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